中国药理学通报2017，Vol.33Issue(9)：1195-1199,5.DOI:10.3969/j.issn.1001-1978.2017.09.003
干扰素抗肿瘤机制及其治疗肿瘤的研究进展
Research progress of interferons in cancer treatment and its mechanism
摘要
Abstract
The interferons(IFNs) are a family of the multifunctional cytokines, which are a kind of highly active and multifunctional glycoproteins.Studies in recent years have shown that IFNs exert a powerful antitumor effect by regulating the proliferation of tumor cells, suppressing tumor metastasis and angiogenesis, and activating antitumor immune response.Combined with other tumor treatment methods, it can inhibit the development of a variety of blood system tumors and solid tumors.In addition, the use of IFNs inducers or IFNs combined with emerging immunotherapy can significantly increase the effectiveness of tumor therapy.This review focuses on our understanding of antitumor mechanism and clinical application of IFNs, and provides some guidance for future research and clinical treatment.关键词
干扰素/肿瘤/分子机制/转移/免疫/临床治疗Key words
interferons/tumor/molecular mechanisms/metastasis/immunity/clinical treatment分类
医药卫生引用本文复制引用
张婷婷,仲金秋,曹玉珠,吴佳伟,陈文星,王爱云,陆茵..干扰素抗肿瘤机制及其治疗肿瘤的研究进展[J].中国药理学通报,2017,33(9):1195-1199,5.基金项目
国家自然科学基金资助项目 (No 81403260,81573859,81673725,81673648) （No 81403260,81573859,81673725,81673648）
江苏高校优秀科技创新团队计划[苏教科(2013)10号文] （2013）
江苏高校品牌专业建设工程资助项目(No PPZY2015A070) （No PPZY2015A070）
江苏高校中药学优势学科建设工程资助项目 (PAPD)[苏政办发(2014)37号文] （PAPD）
江苏普通高校研究生科研创新计划项目(No KYZZ15_0271, KYLX_0972) （No KYZZ15_0271, KYLX_0972）
