中国药理学通报2017，Vol.33Issue(9)：1200-1203,4.DOI:10.3969/j.issn.1001-1978.2017.09.004
内质网应激在糖尿病心肌病中的研究进展
Research progress of endoplasmic reticulum stress in diabetic cardiomyopathy
摘要
Abstract
Diabetic cardiomyopathy(DCM) is a disease independently related with coronary artery atherosclerotic heart disease, hypertensive heart disease, valvular heart disease, congenital heart disease and other heart diseases that are uniquely associated with diabetes mellitus, and the pathological manifestations of DCM are mainly myocardial hypertrophy, interstitial fibrosis, necrosis and apoptosis.Endoplasmic reticulum is the central location of many important cellular functions, and endoplasmic reticulum swelling and functional disorder in diabetic cardiomyocytes, high blood sugar can cause endoplasmic reticulum stress, suggesting that endoplasmic reticulum stress(ERS) may be involved in the pathogenesis of diabetic cardiomyopathy and development.Based on this, this paper summarizes the progress of ERS in diabetic cardiomyopathy from the pathogenesis of diabetic cardiomyopathy, unfolding protein reaction and the related role of ERS in DCM.关键词
糖尿病/心肌病/心肌代谢紊乱/微血管病变/内质网应激/研究进展Key words
diabetes/cardiomyopathy/myocardial metabolic disorders/microvascular disease/endoplasmic reticulum stress/research progress分类
医药卫生引用本文复制引用
周宇,李晶,鲍翠玉..内质网应激在糖尿病心肌病中的研究进展[J].中国药理学通报,2017,33(9):1200-1203,4.基金项目
湖北省自然科学基金资助项目(No 2015CFC773) （No 2015CFC773）
湖北省教育厅科学研究计划项目(No B201696) （No B201696）
湖北科技学院糖尿病专项基金项目(No 2016-18XZ09) （No 2016-18XZ09）
湖北科技学院博士启动基金项目(No BK1432) （No BK1432）
