中国药理学通报2017，Vol.33Issue(9)：1207-1210,4.DOI:10.3969/j.issn.1001-1978.2017.09.006
以p73为靶点的抗肿瘤药物研究进展
Advances in p73-targeting anti-tumor drugs
摘要
Abstract
The transcription factor p73 belongs to the p53 family of tumor suppressors,and can be transcribed into different isoforms with either pro-or anti-apoptotic(TAp73 and △Np73)functions.However,the tumor suppressor activity of TAp73 is inhibited through complex formation with inhibitory proteins(e.g.△Np73,mutant p53,MDM2 and iASPP).Therefore,it is a kind of tumor therapy strategy to reactivate TAp73 through targeting these inhibitors directly or release TAp73 from the complex by targeting their interaction.This review discusses the possible strategies of targeting p73 for its reactivation and the acting mechanism of related compounds.关键词
肿瘤抑制因子/p73/TAp73/凋亡/负调节因子/复合体Key words
tumor suppressor/p73/TAp73/apoptosis/inhibitory proteins/complex分类
医药卫生引用本文复制引用
牟汉川,杨志宽,暴亚锋,张继虹..以p73为靶点的抗肿瘤药物研究进展[J].中国药理学通报,2017,33(9):1207-1210,4.基金项目
国家自然科学基金资助项目(No 81560601) （No 81560601）
昆明理工大学分析测试基金项目(No 2016M2014236022) （No 2016M2014236022）
