中国中医药信息杂志2017，Vol.24Issue(9)：30-34,5.DOI:10.3969/j.issn.1005-5304.2017.09.008
通脉穴贴膏联合前列地尔注射液治疗下肢动脉硬化闭塞症临床观察
Clinical Observation of Tongmai Acupoint Plaster Combined with Alprostadil Injection for Treatment of Lower Extremity Arteriosclerosis Obliterans
摘要
Abstract
Objective To observe the efficacy of Tongmai Acupoint Plaster combined with Alprostadil injection for treatment of lower extremity arteriosclerosis obliterans (ASO). Methods Totally 180 cases of ASO Ⅱ(intermittent claudication period) patients were randomly divided into acupoint sticking group, combination group, Western medicine group, with 60 cases in each group. All groups quit smoking, had diet control, proper exercise, control of blood sugar, stop hypolipidemic and anti-coagulation medicine. The acupoint sticking group was treated with Tongmai Acupoint Plaster, each selected with the efficacy of treatment of lower limbs paralysis acupoint 10-12, alternating dressing; dressing was changed 1 time a day, 40 day as a treatment course. Western medicine group was given Alprostadil injection 10 μg, with 10 mL of normal saline, intravenous infusion, once a day, 15 d as a treatment course, for two courses, with 10 d as interval. Combination group was treated with Tongmai Acupoint Plaster combined with Alprostadil injection, the same as the application method above. The clinical efficacy, the scores of symptoms and signs, the ankle brachial index, blood lipid, the peak value of blood flow in the tibial anterior,posterior tibial, and dorsalis pedis arteries were observed and compared between the 2 groups. Results The total effective rate was 78.33% (47/60) in the acupoint sticking group, 80.00% (48/60) in the Western medicine group, and 93.33%(56/60) in the combination group, with the combination group better than the acupoint sticking group and Western medicine group (P<0.05). There was no statistical significance between acupoint sticking group and Western medicine group (P>0.05). There was statistical significance in scores of symptoms and signs, ankle brachial index before and after treatment in the three groups (P<0.05, P<0.01); There was no statistical significance after treatment (P>0.05). There was statistical significance in blood lipids before and after treatment in acupoint sticking group and combination group (P<0.05). There was statistical significance in tibial anterior, posterior tibial, and dorsalis pedis artery peak before and after treatment in the three groups (P<0.05, P<0.01). Conclusion Tongmai Acupoint Plaster has good efficacy in the treatment of ASO, equivalent with the efficacy of Alprostadil injection, which can regulate blood lipids and improve arterial blood flow. Ther combination of them has better efficacy.关键词
下肢动脉硬化闭塞症/中医外治疗法/穴位贴敷/通脉穴贴膏Key words
lower extremity arteriosclerosis obliterans/TCM external therapy/acupoint application/Tongmai Acupoint Plaster分类
医药卫生引用本文复制引用
吴建华,鞠振国,王轶,张基栋,杨海燕,马超群,陈立侠..通脉穴贴膏联合前列地尔注射液治疗下肢动脉硬化闭塞症临床观察[J].中国中医药信息杂志,2017,24(9):30-34,5.基金项目
江苏省中医药科技项目(BY2015087) （BY2015087）
