中国中医药信息杂志2017，Vol.24Issue(9)：48-50,3.DOI:10.3969/j.issn.1005-5304.2017.09.012
补肾中药对肾虚质大鼠生长发育及脑组织胆碱乙酰化酶含量的影响
Effects of Kidney Reinforcing Medicine on Growth and Development and Brain Choline Acetyl Transferas Content of Rats with Kidney-deficiency Constitution
摘要
Abstract
Objective To discuss the adjustment effects of kidney reinforcing medicine on growth and development and the content of choline acetyl transferase (CHAc) in rats with kidney-deficiency constitution. Methods The method of "cats scare rats" was used to build composite offspring rat models with deficiency and acquired dystrophy, and then the models were divided into model group, Zuogui Pill group and Yougui Pill group. The rats in blank group came from normal pregnant rats. Baby rats were scared and received gavage at the same time. All administration groups received suspension of Zuigui Pills or Yougui Pills. Blank group and model group received the same amount of normal saline, once a day, for 3 months. Growth and development of rats were observed. Weight and food utilization of rats aged 5–8 weeks in each group were recorded. The content of brain CHAc was detected by ELISA. Results When offspring were 5–8 weeks old, weights of rats in the model group were lower than blank group (P<0.01); while weights of rats in Zuogui Pill group and Yougui Pill group increased significantly (P<0.05) and the food utilization was positively correlated with weight; the CHAc content in the model group decreased significantly compared with blank group (P<0.05, P<0.01); while the CHAc content in Zuogui Pill group and Yougui Pill group increased significantly compared with the model group (P<0.01). Conclusion Kidney reinforcing medicine can improve backward growth and development of rats with kidney-deficiency constitution and adjust CHAc in the brain, so as to promote the learning and memory ability of rats with kidney-deficiency constitution.关键词
补肾中药/生长发育/胆碱乙酰化酶/大鼠Key words
kidney reinforcing medicine/growth and development/CHAc/rats分类
医药卫生引用本文复制引用
孙瑜嬬,孙理军,孙耀光,张琪,刘熙如,柏云飞..补肾中药对肾虚质大鼠生长发育及脑组织胆碱乙酰化酶含量的影响[J].中国中医药信息杂志,2017,24(9):48-50,3.基金项目
陕西省重点实验室研究项目(15JS026) （15JS026）
