中国中医药信息杂志2017，Vol.24Issue(9)：68-72,5.DOI:10.3969/j.issn.1005-5304.2017.09.017
益心舒胶囊防潮性能改进研究
Study on Improving Moisture Resistance of Yixinshu Capsule
摘要
Abstract
Objective To investigate the effects of moisture-proof materials and contents on hygroscopicity of Yixinshu Capsules; To improve moisture-proof function of Yixinshu Capsules. Methods The hygroscopicity performance of Yixinshu Capsules was analyzed with the indexes of moisture absorption rate and critical relative humidity (CRH), and effects of soluble starch, maize starch, dextrin, lactose, mannitol, calcium hydrogen phosphate, ethylcellulose, microcrystalline cellulose, hypromellose and low-substituted hydroxypropyl cellulose on hygroscopicity of Yixinshu Capsules were compared. The effects of optimized excipients and capsule contents after granulation on hygroscopicity of Yixinshu Capsules were tested. Results Lactose, microcrystalline cellulose and mannitol were the most appropriate moisture-proof excipients for Yixinshu Capsules with balanced moisture absorption rate of 18.04%, for which the best proportion of Yixinshu Capsules to excipients was 1 to 0.1 (wt%). The balanced moisture absorption rate of the powders were 14.87%, 14.39%, and 15.38%, respectively, whereas the granules were 10.75%, 10.29%, and 11.13%, respectively. Conclusion The selected excipients can effectively reduce the hygroscopic rate of the Yixinshu Capsules, and its granules can promote the moisture resistance of Yixinshu Capsules.关键词
益心舒胶囊/辅料/吸湿性/吸湿率/临界相对湿度Key words
Yixinshu Capsules/excipients/hygroscopicity/moisture absorption rate/critical relative humidity分类
医药卫生引用本文复制引用
李真真,王杰,易红,臧琛,赵庆贺,陈燕军..益心舒胶囊防潮性能改进研究[J].中国中医药信息杂志,2017,24(9):68-72,5.基金项目
国家科技重大专项-重大新药创制(2014ZX09201021-009) （2014ZX09201021-009）
