重庆医学2017，Vol.46Issue(23)：3169-3172,3176,5.DOI:10.3969/j.issn.1671-8348.2017.23.001
广西壮族人群白细胞介素-27基因rs17855750G/T、rs40837A/G多态性分布特点
The distribution characteristics of interleukin-27 gene rs17855750 G/T and rs40837 A/G polymorphism of Zhuang populations in Guangxi
摘要
Abstract
Objective To investigate the distribution characteristics of interleukin-27 gene rs17855750 G/T,rs40837 A/G polymorphism in Zhuang populations of Guangxi,and to compare the distribution differences of genotype and allele frequencies of interleukin-27 gene rs17855750 G/T,rs40837 A/G polymorphisms among different races.Methods The interleukin-27 gene rs17855750 G/T,rs40837 A/G polymorphisms were detected by SNaPshot SNP genotyping technique on 168 persons in Zhuang populations of Guangxi,frequencies of genotype and allele of interleukin-27 gene rs17855750 G/T,rs40837 A/G polymorphisms were analyzed in Zhuang populations,and was compared with the other four populations (HapMap-HCB,HapMap-JPT,HapMap-YRI,HapMap-TSI) from HapMap database.Results The most common genotype and allele of interleukin-27 gene rs17855750 G/T polymorphysms were TT(70.2％) and G(50.3％) in Zhuang populations of Guangxi,and the most common genotype and allele of interleukin-27 gene rs40837 G/T polymorphysms were AC(35.7 ％) and C(52.1 ％).There were no significant differences in the genotype and allele frequencies of interleukin-27 gene rs17855750 G/T,rs40837 A/G polymorphysms between male and female gender in Zhuang populations of Guangxi(P＞0.05).The frequencies of allele and genotype distribution of IL-27 gene rs17855750 G/T polymorphisms were not significantly different when compared with HapMap-HCB(P＞0.05),but were significantly different when compared with HapMap-JPT,HapMap-TSI and HapMap-YRI(P＜0.01);The frequencies of allele and genotype distribution of intetleukin-27 gene rs40837 A/G polymorphisms were significantly different when compared with HapMap-HCB(P＜ 0.05),and were significantly different when compared with HapMap-JPT,HapMap-YRI and HapMap-TSI(P＜0.01).Conclusion There are significant differences in the frequencies of allele and genotype distribution of interleukin-27 gene rs17855750 G/T,rs40837 A/G between Zhuang populations and other ethnic populations,and this variation may lead to a variety of clinical manifestation and morbidity of some diseases.关键词
白细胞介素27/多态性,单核苷酸/分布特点/广西[壮族自治区]/种族关系Key words
interleukin-27/polymorphism, single nucleotide/distribution characteristics/Guangxi/race relations分类
医药卫生引用本文复制引用
胡仁统,王俊利,韦叶生,陆潞,韦贵将,黄可,廖品琥,唐毓金..广西壮族人群白细胞介素-27基因rs17855750G/T、rs40837A/G多态性分布特点[J].重庆医学,2017,46(23):3169-3172,3176,5.基金项目
国家自然科学基金资助项目(81260315、81541136) （81260315、81541136）
广西自然科学基金资助项目(2012GXNSFAA053169) （2012GXNSFAA053169）
广西卫生厅自筹经费科研课题项目(Z2014520) （Z2014520）
百色科技攻关项目(20160610) （20160610）
广西高校青年教师基础能力提升项目(KY2016YB347). （KY2016YB347）
