儿科药学杂志2017，Vol.23Issue(8)：38-41,4.DOI:10.13407/j.cnki.jpp.1672-108X.2017.08.014
1018例癫痫患儿丙戊酸钠血药浓度监测及影响因素分析
Serum Concentration Monitoring of Sodium Valproate and Its Influential Factors in 1,018 Cases Pediatric Epilepsy
李赛 1宁颖 1桂洪芹 1范凯健 2黄昕1
作者信息
- 1. 扬州大学医学院附属淮安市妇幼保健院,江苏淮安223001
- 2. 上海市宝山区中西医结合医院,上海201900
- 折叠
摘要
Abstract
Objective:To provide references for clinical drug administration by analyzing the serum concentrations of sodium valproate (VPA) in pediatric epilepsy.Methods:High performance liquid chromatography was used to detect the serum concentrations of sodium valproate in 1,018 cases pediatric epilepsy.The impact of age,gender,dose and dosage forms on the serum concentrations of VPA and the relation between the serum concentrations of VPA and therapeutic effect were analyzed.Results:Among the serum concentrations of VPA in 1,018 cases,528 cases (51.9％) were lower than therapeutic window concentration,464 cases (45.6％) were in the therapeutic window concentration,26 cases (2.6％) were higher than therapeutic window concentratio.The impact of age,gender and dose on the serum concentrations of VPA had statistical differences (P＜0.05),while the dosage form had no statistical difference (P＞0.05).There was statistical difference between the serum concentrations of VPA and therapeutic effect (P＜0.05).Conclusion:Serum concentration of VPA in pediatric epilepsy children is related to age,gender,drug dose and other factors.There are great individual differences in serum concentration of sodium valproate among children.The monitoring of sodium valproate will be great important reference to drug administration for pediatric epilepsy.关键词
儿童/癫痫/丙戊酸钠/血药浓度/影响因素Key words
children/epilepsy/sodium valproate/serum concentration/infunential factors分类
医药卫生引用本文复制引用
李赛,宁颖,桂洪芹,范凯健,黄昕..1018例癫痫患儿丙戊酸钠血药浓度监测及影响因素分析[J].儿科药学杂志,2017,23(8):38-41,4.
