高电压技术2017，Vol.43Issue(8)：2464-2469,6.DOI:10.13336/j.1003-6520.hve.20170731004
驻极体外静电场对猪胰岛素结构和介电特性的影响
Effect of External Electrostatic Field of Electrets on Structure and Dielectric Property of Porcine Insulin
摘要
Abstract
In order to study the effects of external electrostatic field of electret on structure and dielectric property of procine insulin,and to provide theory evidence for the study of the electret to increase the effect of insulin on blood glucose reducing,the corona charged 500 V,1 000 V,and 1 500 V polypropylene (PP) electrets were acted on insulin as electric field source.The 1H-NMR spectroscopy,gel electrophoresis,and piezoelectric d33 coefficient were determined,respectively.The results show that:1) PP electret with different surface potential can produce stable electrostatic field on both sides of the insulin solution or insulin patch.The higher the surface potential of the electret is,the stronger the electrostatic field would be.2) The external electrostatic field of PP electret has no obvious effects on the primary and secondary structures of insulin.3) The piezoelectric d33 coefficients for insulin patches treated by 500 V,1 000 V,and 1 500 V PP electrets are 15.7,21.3,and 32.0 folds more than those of the non-electret treated insulin patch.4) The 1H-NMR spectroscopy indicates that the hydrogen network of insulin structure is changed after the action of electret.So,electrostatic field produced by PP electret leads to the weak polarization of the insulin molecules,alters the charging characteristic of the insulin,and it is helpful for the formation of insulin monomers.Therefore,electrets can increase the effect of insulin on blood glucose reducing.关键词
驻极体/胰岛素/静电场/极化/聚丙烯Key words
electrets/insulin/electrostatic field/polarization/polypropylene引用本文复制引用
崔黎丽,苑旺,梁媛媛,郭鑫,黄平,徐立丽,江键..驻极体外静电场对猪胰岛素结构和介电特性的影响[J].高电压技术,2017,43(8):2464-2469,6.基金项目
国家自然科学基金(51477175).Project supported by National Natural Science Foundation of China (51477175). （51477175）
