高校化学工程学报2017，Vol.31Issue(4)：769-775,7.DOI:10.3969/j.issn.1003-9015.2017.04.003
L-酒石酸二乙酯萃取拆分氧氟沙星对映体的研究
Enantiseparation of Ofloxacin Enantimers via Diethyl L-Tartrate Extraction
摘要
Abstract
Levofloxacin is a widely used antibacterial drug which has extraordinary therapeutic effects for all types of inflammation caused by Gran-negative bacteria. Currently, levofloxacin is usually produced via enantioseparation, and low solubility and selectivity of ofloxacin enantiomers are the main problems needed to be solved. This work used acetic acid as a cosolvent to increase ofloxacin solubility in water, and diethyl L-tartrate was used to enantiseparate ofloxacin enantiomers. Effects of extraction temperature, and diethyl L-tartrate, acetic acid and ofloxacin enantiomer concentration on enantiseparation were studied. The results show that the addition of acetic acid can significantly increase ofloxacin solubility in aqueous phase. When the concentrations of diethyl L-tartaric, ofloxacin and acetic acid one are 0.2 mol·L-1, 12000 ppm and 0.1 mol·L-1, respectively, the ofloxacin enantiomer chiral separation coefficient is 1.39 at 25℃ . The results obtained in this study are helpful for large-scale levofloxacin manufacture.关键词
液液萃取/手性拆分/氧氟沙星/手性药物Key words
liquid-liquid extraction/chiral separation/ofloxacin/chiral drug分类
化学化工引用本文复制引用
张维阳,崔兴,蒋淑娴,宋慧洁,周容帆,叶向群,何潮洪..L-酒石酸二乙酯萃取拆分氧氟沙星对映体的研究[J].高校化学工程学报,2017,31(4):769-775,7.基金项目
国家自然科学基金项目(21576231). （21576231）
