高校化学工程学报2017，Vol.31Issue(4)：906-910,5.DOI:10.3969/j.issn.1003-9015.2017.04.021
双环[3.2.1]辛烷-2,4-二酮的改进合成
Improvement of Bicyclo[3.2.1]octane-2,4-dione Synthesis
摘要
Abstract
Bicyclo[3.2.1]octane-2,4-dione was synthesized using 2-norbornanone via Mannich reaction, Baeyer-Villiger reaction and self-condensation reaction. Steam distillation is used in Mannich reaction for product separation and to facilitate the transformation of intermediates into product, which combines reaction and separation together. Moreover, variation of addition sequence of methanol and hydrogen peroxide in Baeyer-Villiger reaction can improve product yields by avoiding excessive oxidation. The total yield of the final product is 61.5% under optimized conditions.关键词
2-降莰烷酮/反应分离/Mannich反应/Baeyer-Villiger反应/双环[3.2.1]辛烷-2,4-二酮Key words
2-norbornanone/coupling of reaction and distillation separation/Mannich reaction/Baeyer- Villiger reaction/bicyclo[3.2.1]octane-2/4-dione分类
化学化工引用本文复制引用
钱超,高武成,付水香,陶明,廖祖态,陈新志..双环[3.2.1]辛烷-2,4-二酮的改进合成[J].高校化学工程学报,2017,31(4):906-910,5.基金项目
国家自然科学基金(21376213,21476194) （21376213,21476194）
国家重点研发计划项目(2016YFB0301800). （2016YFB0301800）
