广西医科大学学报2017，Vol.34Issue(8)：1145-1149,5.DOI:10.16190/j.cnki.45-1211/r.2017.08.007
NT-proBNP、CysC和PCT对急性冠脉综合征患者预后评估的应用价值
The value of NT-proBNP, CysC and PCT application in the prognostic assessment of patients with ACS
摘要
Abstract
Objective:To investigate the value of N-terminal pro-brain natriuretic peptide (NT-proBNP),cystatin C (CysC) and procalcitonin (PCT) levels in the prognostic assessment of patients with acute coronary syndrome (ACS).Methods:120 patients with ACS were divided into unstable angina pectoris (UAP) group and acute myocardial infarction (AMI) group,with 60 cases each,and 60 healthy vonlenteers were enrolled as a control group.The levels of NT-proBNP,CysC and PCT in plasma and Gensini sore were compared among groups.After 12 months follow-up,the changes of above indexes were observed,and the prognostic value was analyzed.Results:The levels of NT-proBNP,CysC and PCT in plasma and Gensini score in UAP group and AMI group were significantly higher than those in the control group,whereas these indexes in AMI group were notably higher than UAP group (P＜0.05).The levels of NT-proBNP,CysC and PCT in plasma and Gensini score were significantly increased with the numbers of diseased coronary arteries increased (P＜0.05).Pearson correlation analysis showed that the levels of NT-proBNP,CysC and PCT were positively correlated with Gensini score (P＜0.05).Patients with major adverse cardiac events (MACE) had higher levels of NT-proBNP,CysC and PCT than those without (P＜0.05).The area under the ROC curve were 0.825,0.734 and 0.670,the sensibility were 68.8％,81.3％ and 75.0％,and the specificity were 84.1％,68.2％ and 56.8％,respectively in NT-proBNP,CysC and PCT.Conclusion:The levels of NT-proBNP,CysC and PCT in plasma were correlated with the lesion degree of coronary artery and prognosis.NT-proBNP,CysC and PCT were the important predictors in assessing prognosis for patients with ACS.关键词
急性冠脉综合征/N末端脑钠肽前体/胱抑素C/PCT/预后Key words
acute coronary syndrome/N-terminal pro-brain natriuretic peptide/cystatin C/procalcitonin/prognosis分类
医药卫生引用本文复制引用
刘洪军,杨猛,张开忠..NT-proBNP、CysC和PCT对急性冠脉综合征患者预后评估的应用价值[J].广西医科大学学报,2017,34(8):1145-1149,5.基金项目
重庆市卫生计生委医学科研课题资助项目(No.2015ZBXM093) （No.2015ZBXM093）
