广西医科大学学报2017，Vol.34Issue(8)：1171-1173,3.DOI:10.16190/j.cnki.45-1211/r.2017.08.014
C反应蛋白和降钙素原检测在儿童原发性肾病综合征病情评估中的应用研究
The application of C-reactive protein and procalcitonin in children with primary nephrotic syndrome
摘要
Abstract
Objective:To study the clinical applications of C-reactive protein (CRP) and serum procalcitonin (PCT) in children with primary nephrotic syndrome (PNS).Methods:Ninety-two children with PNS admitted in our hospital from December 2009 to December 2014 were enrolled in this study.Among them,65 children with simplicity were enrolled in the simplicity group,and 27 children with nephritis were enrolled in the nephritis group.Meanwhile,50 healthy children were selected into the control group.The CRP level was detected by immunoturbidimetry,and PCT level was detected by electrochemiluminescence.The levels of CRP,PCT,urea nitrogen (BUN),and creatinine (Cr) among groups were compared.Results:The levels of CRP and PCT were (11.64±13.56) mg/L and (0.89±1.72) μg/L in the simplicity group,and (21.81±20.31) mg/L and (1.56±1.19) μg/L in the nephritis group.They both had significantly elevated compared to the levels of CRP and PCT in control group,which were (3.43±2.29) mg/L and (0.16± 0.13) μg/L,respectively (P＜0.05).In addition,the level of CRP in simplicity group was positively correlated with BUN in PNS children before treatment (r=0.252,P＜0.05).The similar results of the level of PCT in simplicity group were observed (r=0.243,P＜0.05).Conclusion:CRP and PCT were possible to take part in the development of PNS,which might contribute to the diagnosis of PNS.They could be used as the important markers in the monitoring of PNS.关键词
C反应蛋白/降钙素原/原发性肾病综合征/儿童Key words
C-reactive protein/procalcitonin/primary nephrotic syndrome/children分类
医药卫生引用本文复制引用
郑志方,陈国利,刘霞..C反应蛋白和降钙素原检测在儿童原发性肾病综合征病情评估中的应用研究[J].广西医科大学学报,2017,34(8):1171-1173,3.基金项目
承德市科学技术研究与发展计划基金资助项目(No.20151028) （No.20151028）
