化工进展2017，Vol.36Issue(9)：3436-3446,11.DOI:10.16085/j.issn.1000-6613.2017-0159
新型纳米棒药物载体的合成及性能研究进展
Fabrication and properties of novel nanorods drug carriers
摘要
Abstract
Nanorods with unique structure,excellent performance and important biomedical applications value,have gradually become a novel drug carrier. The paper discussed the recent research progresses in nanorods drug carriers,including fabrications and applications of some typical drug carriers,such as Au nanorods,hydroxyapatite(HAP)nanorods, and mesoporous silica(MSP) nanorods. The general synthesis process of drug carries(Au nanorods,Au@SiO2 nanorods,Au@C nanorods,hollow Au nanorods)were primarily analyzed. The surface modification,functionalization,loading and controlled release of those carries based on Au nanorods were briefly discussed. The controlled-release properties of some familiar nanorods carriers were analyzed and compared. Three common release methods for nanorods carries were presented. Direct-release with the as-dispersed carries,is economical and practicable,but the required carrier dosage is large and easy to loss. The release method with dialysis bag requires the lower carrier dosage,does not need separation but needs to purchase dialysis bag. The third method,release in cuvette,is mostly used at photosensitive carriers. Furthermore,the size andin vitro cytotoxicity of nanorods carriers were discussed in detail,and their metabolism propertiesin vivosuch as distribution and immune clearance were also introduced. Finally,the outlook on the development of nanorods carriers was presented. Future research on nanorods carries maybe focus on multiple stimuli-responsive heterogeneous carries based on nanorods,hollow nanorods carries and nanotube carries.关键词
纳米棒载体/复合材料/纳米材料/分布/细胞毒性Key words
nanorods carriers/composites/nanomaterials/distributions/cytotoxicity分类
医药卫生引用本文复制引用
李薇,赵一凡,曹媛媛,胡平静,李祥子..新型纳米棒药物载体的合成及性能研究进展[J].化工进展,2017,36(9):3436-3446,11.基金项目
安徽省高校自然科学基金重点项目(KJ2015A158)、安徽省高校优秀青年人才支持计划重点项目(gxyqZD2016169)、中国博士后科学基金面上项目(2015M581731)、江苏省博士后科研资助计划项目(1501066C)及大学生创新创业计划项目(201610368119,201510368040,201510368121). （KJ2015A158）
