解剖学杂志2017，Vol.40Issue(4)：382-385,4.DOI:10.3969/j.issn.1001-1633.2017.04.004
当归多糖治疗小鼠乙醇性肝损伤中丙二醛、超氧化物歧化酶及谷胱甘肽过氧化物酶的变化及意义
Effect of Angelica sinensis polysaccharide on serum malondialdehyde, superoxide dismutase and glutathione peroxidase of alcohol-induced hepatic injured mice
摘要
Abstract
Objective: To explore the effect of Angelica sinensis polysaccharide on expressions of malondialdehyde(MDA),superoxide dismutase(SOD)and glutathione peroxidase (GSH-Px) in alcohol injured mouse livers and its significance.Methods: A mouse model of acute alcoholic liver injury was established by a one-time gavage of high concentration of alcohol.The general situation of the mice was then observed by intraperitoneal injection of Angelica sinensis polysaccharides for 6 days.The changes of MDA,SOD and GSH-Px in serum biochemistry were detected in different conditions.Changes of liver morphology and structure were observed with light microscope.Results: After alcoholic liver injury in mice,serum MDA increased significantly,and SOD and GSH-Px decreased significantly.At the same time,the liver tissue showed diffuse steatosis.After being treated with Angelica sinensis polysaccharide,along with the structure of the liver tissue repair,serum MDA decreased significantly,and SOD and GSH-Px increased.Conclusion: Angelica sinensis polysaccharide enable to protect the hepatocytes by blocking lipid peroxidation.And,serum MDA,SOD and GSH-Px could be used to biomarkers for hepatic injury,progression and outcomes.关键词
当归多糖/丙二醛/超氧化物歧化酶/谷胱甘肽过氧化物酶/肝损伤/小鼠Key words
Angelica sinensis polysaccharide/malondialdehyde/superoxide dismutase/glutathione peroxidase/liver injury/mouse引用本文复制引用
贾书花,王东,张宏峰,赖雅文,王改琴..当归多糖治疗小鼠乙醇性肝损伤中丙二醛、超氧化物歧化酶及谷胱甘肽过氧化物酶的变化及意义[J].解剖学杂志,2017,40(4):382-385,4.基金项目
长治医学院科技创新团队项目(CX201415) （CX201415）
山西省大学生创新创业项目(2014301) （2014301）
