生态与农村环境学报2017，Vol.33Issue(8)：737-742,6.DOI:10.11934/j.issn.1673-4831.2017.08.009
4-壬基酚对斑马鱼(Danio rerio)胚胎/仔鱼的毒性效应
Toxic Effects of 4?Nonyl Phenol on Zebrafish ( Danio rerio ) Embryo /Larva
摘要
Abstract
4?Nonylphenol (4?NP), a stable environmental endocrine disruptor, exerts negative effects on the growth and development of organisms. Danio rerio embryos were exposed to a series of concentrations of 4?NP at 2. 0, 5. 0, 10. 0, 25. 0, 50. 0 and 125. 0μg·L-1 for 120 h. During the exposure, the mortality, hatching rates and abnormalities of embry?os, as well as the body length and heart rates in 30 s were recorded everyday till the larva in the control group began to die as a result of hunger. The results show that the LC50 of Danio rerio embryos exposed to 4?NP after 48, 72 and 96 h were 131. 4, 47. 2 and 26. 8 μg·L-1 , respectively. The hatching rate of Danio rerio embryos significantly declined due to the lethal effect of 125. 0 μg·L-1 of 4?NP. In addition, exposure to 4?NP significantly increased the tail malformation and pericardial cyst rates of Danio rerio embryos. A positive dose?response relationship was observed in the tail malformation rates. Compared to the control group, the Danio rerio larva in all 4?NP treatment groups had shorter body length and less 30 s heart rates. These results suggested that exposure to 2. 0μg·L-1 concentration of 4?NP can exert teratogenic and le?thal effects on the Danio rerio embryos.关键词
4-壬基酚/斑马鱼/胚胎发育/毒性效应Key words
4⁃nonylphenol/Danio rerio/embryonic development/toxic effect分类
资源环境引用本文复制引用
张慧,姜锦林,张宇峰,单正军,卜元卿,田丰..4-壬基酚对斑马鱼(Danio rerio)胚胎/仔鱼的毒性效应[J].生态与农村环境学报,2017,33(8):737-742,6.基金项目
环保公益性行业科研专项(201309026) （201309026）
