实验动物与比较医学2017，Vol.37Issue(3)：209-213,5.DOI:10.3969/j.issn.1674-5817.2017.03.007
不同糖油比例高脂饲料建立高脂血症大鼠模型的比较
A Comparison on Hyperlipidemia Rat Models Induced by High-fat Diet with Different Proportions of Sugar and Oil
摘要
Abstract
Objective To compare hyperlipidemia rat models induced by high-fat diet with different proportions of sugar and oil.Methods Fourty rats were divided into normal control group and three high-fat diet (Ⅰ,Ⅱ and Ⅲ) groups with 10 rats per each.The normal control group was fed with normal diet,and the other three groups were fed with high-fat diet with different proportions of sugar and oil for 6 weeks respectively.The body weight and the total cholesterol (TC),triglyceride (TG),high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) in serum were detected weekly.Results No significant difference were observed on body weight among different groups.The TC,LDL-C and TC/HDL-C ratios in all high-fat diet groups were higher than those of normal control group at each time point.The TG in high-fat diet Ⅱ group was higher than normal control group at each time point,but was only higher at the first 4 weeks in high-fat diet Ⅰ group,and no significant difference in high-fat diet Ⅲ group except at second week.Conclusion Both high-fat diet Ⅰ and Ⅱ can induce combined hyperlipidemia rat models rapidly and steady,and high-fat diet Ⅱ is more superior.High-fat diet Ⅲ may be applied to induce hypercholesterolemia in rat.关键词
高脂饲料/糖和油/高脂血症/大鼠Key words
High-fat diet/Sugar and oil/Hyperlipidemia/Rat分类
生物科学引用本文复制引用
覃辉艳,王绍龙,温平镜,赵鹏,李彬,张洁宏..不同糖油比例高脂饲料建立高脂血症大鼠模型的比较[J].实验动物与比较医学,2017,37(3):209-213,5.基金项目
广西科技基础条件平台建设项目(13-29-04) （13-29-04）
