实验动物与比较医学2017，Vol.37Issue(3)：252-256,5.DOI:10.3969/j.issn.1674-5817.2017.03.017
抗原处理相关转运体基因多态性与疾病相关性的研究进展
Advances in Research on Relationship between Transporter Associate with Antigen Processing Gene Polymorphism and Diseases
摘要
Abstract
Transporter associate with antigen processing (TAP) is a heterodimer which plays a crucial role in antigen presenting process by transporting endogenous antigen peptide from the cytoplasm to the endoplasmic reticulum where can be bound by the major histocompatibility complex (MHC) class Ⅰ molecules and further be recognized by CD8+T lymphocyte.Polymorphisms of TAP gene and the expression level of TAP protein are associated with susceptibility to certain specific diseases including tumor,autoimmune disease,viral disease and infectious diseases.Here,some similar comparative medicine researches of TAPs in laboratory animals to diseases associations are reviewed.关键词
抗原处理相关转运体(TAP)/多态性/疾病/相关性Key words
Transporter associate with antigen processing (TAP)/Polymorphism/Diseases/Association分类
生物科学引用本文复制引用
王兴童,陈洪岩,韩凌霞..抗原处理相关转运体基因多态性与疾病相关性的研究进展[J].实验动物与比较医学,2017,37(3):252-256,5.基金项目
国家科技支撑计划(2015BAI07B02-02),中国农业科学院基本科研业务费专项(Y2016PT41),中国农业科学院基本科研业务费专项(302016013) （2015BAI07B02-02）
