天津科技大学学报2017，Vol.32Issue(4)：20-23,35,5.DOI:10.13364/j.issn.1672-6510.20160188
一类苄基咔唑衍生物的合成及其芳香化酶抑制活性
Synthesis and Aromatase Inhibitory Activities of Some Benzyl Carbazole Derivatives
摘要
Abstract
Many natural substances and drug molecules with the carbazole structure have a broad range of biological and pharmacological activities.Based on our previous discovery that benzyl carbazole possesses aromatase inhibitory activity, ten substitutes were synthesized(the first seven compounds are unreported in literature),and their structure was confirmedby 1H NMR.Their aromatase inhibitory activities were assayed in vitro at enzyme levels and the structure activity relationship was summarized.This research can provide some basic data and ideas for the further search of new benzyl carbazole deriva-tives with higher aromatase inhibitory activities.关键词
苄基咔唑衍生物/合成/芳香化酶抑制剂Key words
benzyl carbazole derivatives/synthesis/aromatase inhibitor分类
医药卫生引用本文复制引用
戴玉杰,刘艳春,孙紫悦,宋智丹,刘伟,张秀利..一类苄基咔唑衍生物的合成及其芳香化酶抑制活性[J].天津科技大学学报,2017,32(4):20-23,35,5.基金项目
国家自然科学基金资助项目(21272171) （21272171）
