中国组织工程研究2017，Vol.21Issue(24)：3833-3838,6.DOI:10.3969/j.issn.2095-4344.2017.24.011
改良兔防御素1对周围神经损伤修复后神经再生的作用
Effect of modified rabbit defensin 1 on peripheral nerve regeneration
摘要
Abstract
BACKGROUND:Peripheral nerve injury is a common disease in clinic, which severely affects the patients' quality of life. How to promote peripheral nerve regeneration is an issue of concern.OBJECTIVE:To study the effect of modified rabbit defensin 1 on peripheral nerve regeneration and functional recovery. METHODS: Eighteen Sprague-Dawley rats were randomly divided into three groups. The rat sciatic nerves were transected and bridged by biodegenerated chitin conduits, followed by the injection of neurotrophic factor (group 1), modified rabbit defensin 1 (group 2) and normal saline (control group) into the gluteus, respectively, for consecutive 7 days. RESULTS AND CONCLUSION: The sciatic nerve function index in the groups 1 and 2 was higher than that in the control group at 4 weeks postoperatively. The order of motor nerve conductive velocity was as follows: group 1 > group 2 > control group. The diameter regenerated fibers and axons, and the myelin thickness in the group 2 were less than those in the group 1, but were more than those in the control group. These results indicate that the modified rabbit defensin 1 can promote peripheral nerve regeneration, which may be related with the clearance of residual myelin by macrophages and the improvement in nerve regeneration environment.关键词
组织构建/组织工程/防御素/周围神经再生/坐骨神经指数/运动神经传导速度/再生神经纤维直径/轴突直径/髓鞘厚度/G-ratio/安徽省自然科学基金分类
医药卫生引用本文复制引用
徐春归,张积森,许新忠,荆珏华..改良兔防御素1对周围神经损伤修复后神经再生的作用[J].中国组织工程研究,2017,21(24):3833-3838,6.基金项目
安徽省自然科学基金项目(1608085QH206) （1608085QH206）
安徽医科大学校科研基金(2015xkj017) Funding:the Natural Science Foundation of Anhui Province, No. 1608085QH206 （2015xkj017）
the Research Foundation of Anhui Medical University, No. 2015xkj017 （）
