西南国防医药2017，Vol.27Issue(8)：788-790,3.DOI:10.3969/j.issn.1004-0188.2017.08.003
毛兰素固体脂质纳米粒的制备及稳定性的初步研究
Preparation of erianin solid lipid nanoparticle and prelimininary study on its stability
摘要
Abstract
Objective To prepare erianin (ER) solid lipid nanoparticle (SLN) and conduct preliminary study on its stability and other indexes.Methods Emulsion evaporation-solidification at low temperature was taken to prepare ER SLN.The entrapment efficiency,drug loading capacity,particle size,potential and stability were investigated.Results The particle size of the ER SLN prepared was 163.3 nm,the Zeta potential was-26.8 mV,the entrapment efficiency was 72.6％,and the drug loading capacity was 12.7％.The appearance and entrapment efficiency of ER SLN had no significant change when it was placed under 4 ℃ conditions for four weeks.Conclusion The preparation of ER SLN by emulsion evaporation-solidification at low temperature is feasible.The sample prepared has high stability under 4 ℃ conditions.关键词
毛兰素/固体脂质/纳米粒/乳化蒸发/低温固化/稳定性Key words
ER/SLN/emulsion evaporation-solidification at low temperature/stability分类
医药卫生引用本文复制引用
陈相旭,徐文强,宋宗辉,王玲洁,于波涛..毛兰素固体脂质纳米粒的制备及稳定性的初步研究[J].西南国防医药,2017,27(8):788-790,3.基金项目
四川省科技厅支撑项目(2010JY0029) （2010JY0029）
