西南国防医药2017，Vol.27Issue(8)：794-796,3.DOI:10.3969/j.issn.1004-0188.2017.08.005
氨甲环酸结合术后引流管夹闭在脊柱侧凸矫形术中的应用
Application of tranexamic acid combined with postoperative draiuage tube clipping in scoliosis correction
摘要
Abstract
Objective To evaluate the efficacy and safety of the application of tranexamic acid combined with postoperative drainage tube clipping in reducing blood loss in the perioperative period of scoliosis correction.Methods A total of 58 patients with idiopathic scoliosis treated with posterior screw rod system orthopedic fixation and bone graft at facet joint but not treated with osteotomy were selected and randomly divided into an experiment group and a control group.The experiment group was treated with 15 mg/kg tranexamic acid by intravenous injection 15 min before the operation and maintained at 10 mg/(kg· h) during operation till the end of operation,after which the drainage tube was clipped for eight hours;the control group was treated with equivalent normal saline 15 min before and during the operation,after which the drainage tube was clipped for eight hours.The volume of drainage 24 hours after the operation,the total volume of drainage,autologous blood transfusion amount,allogeneic blood transfusion rate,indwelling catheter time and hemoglobin value one day,three days and seven days after the operation,and postoperative wound infection rate and other indexes between the two groups were compared.Results The postoperative volume of drainage,the total volume of drainage,autologous blood transfusion amount,blood transfusion rate and indwelling catheter time in the experiment group were much lower than those in the control group;the hemoglobin value 1-7 days after the operation was significantly higher than that in the control group (P ＜ 0.05).Conclusion Tranexamic acid administered intravenously combined with postoperative clipping of drainage tube for eight hours can effectively and safely control the blood loss in the perioperative period of scoliosis correction.关键词
脊柱侧弯/失血量/氨甲环酸/夹闭/引流管Key words
scoliosis/blood loss/tranexamic acid/clipping/drainage tube分类
医药卫生引用本文复制引用
奉国成,王均,陆维,徐伟,梁金龙,陆声,徐永清..氨甲环酸结合术后引流管夹闭在脊柱侧凸矫形术中的应用[J].西南国防医药,2017,27(8):794-796,3.基金项目
国家自然科学基金(90000016-4815-4) （90000016-4815-4）
成都军区医学科学研究计划项目(C12048) （C12048）
