眼科新进展2017，Vol.37Issue(8)：736-738,742,4.DOI:10.13389/j.cnki.rao.2017.0186
2型糖尿病合并皮质性白内障患者房水中Txnip、Trx的定量检测及相关性分析
Quantitative detection and correlation analysis of Txnip,Trx in aqueous humor of cortical cataract patients with type 2 diabetes
摘要
Abstract
Objective To investigate the level and correlation between Thioredoxin (Trx) and Thioredoxin interacting protein (Txnip) in aqueous humor of cortical cataract patients with type 2 diabetes.Methods The Txnip and Trx levels were determined by Elisa in aqueous humor of 60 cataract patients with type 2 diabetes,which were divided into group A (control group,HbA1c ＜5.5％),group B (5.5％ ≤HbA1c ＜6.5％) and group C (HbA1c＞6.5％),and each group contains 20 patients.Results The level of Txnip in group B was higher than that in group A,while that in group C was the highest,there were statistical differences (all P ＜ 0.05).Compared with group A,the level of Trx in group B was increased,while that in group C was the lowest,there were statistical differences (all P ＜ 0.05).The level of Trx was positive correlated with Txnip in group A (r =0.810,P =0.000),but negative correlated with Txnip in group C (r =-0.809,P =0.000) and degree of cataract in group C (r =-0.727,P =0.001).Logistic regression analysis revealed that Txnip and HbAl c were risk factors of cortical cataract.Conclusion Trx and Txnip may play an important role in the development of diabetic cataract.关键词
糖尿病性白内障/硫氧还蛋白/硫氧还蛋白互作蛋白/氧化应激Key words
diabetic cataract/Thioredoxin/Thioredoxin interacting protein/oxidative stress分类
医药卫生引用本文复制引用
姜凌峰,石栋,阎启昌..2型糖尿病合并皮质性白内障患者房水中Txnip、Trx的定量检测及相关性分析[J].眼科新进展,2017,37(8):736-738,742,4.基金项目
国家自然科学基金资助项目(编号:81600777)National Natural Science Foundation of China (No:81600777) （编号:81600777）
