中国临床药理学与治疗学2017，Vol.22Issue(7)：738-742,5.
姜黄素对肝肺综合征大鼠的保护作用
Curcumin alleviate intrapulmonary inflammation in rat experimental hepatopulmonary syndrome
摘要
Abstract
AIM:To evaluate the protective effect of curcumin in an experimental model of hepatopulmonary syndrome (HPS) induced by bile duct ligation in rats.METHODS:One week after surgery,curcumin (50 mg· kg-1 · d-1) was administered intragastrically for two weeks.Arterial blood gas analysis was performed.Plasma TNF-α and ALT level was measured.Pathological change in rat lung tissue and liver tissue were observed through HE staining.CD68,TNF-α and NF-κB P-65 were detected by immunofluorescence,and IκBα/p-IκBα was assessed by Western blotting.RESULTS:Curcumin alleviated lung tissue and pulmonary intravascular monocyte accumulation and significantly decreased AaPO.Also,pulmonary TNF-α level and lung tissue NF-κB activity were reduced.CONCLUSION:Curcumin can protect HPS rat from pulmonary inflammation injury.The mechanism may be related with anti-inflammation by inhibition of TNF-α/NF-κB.关键词
肝肺综合征/姜黄素/TNF-α/NF-κBKey words
hepatopulmonary syndrome/curcumin/TNF-α/NF-κB分类
医药卫生引用本文复制引用
李旭炯,刘安,陈云霞,李淑芬..姜黄素对肝肺综合征大鼠的保护作用[J].中国临床药理学与治疗学,2017,22(7):738-742,5.基金项目
科技部重大新药创制重大专项(2014ZX09304307-001) （2014ZX09304307-001）
长治医学院科技创新团队项目(CX201509) （CX201509）
