中国临床药理学与治疗学2017，Vol.22Issue(7)：749-754,6.
黄芩苷对哮喘大鼠气道重塑作用的实验研究
Effect of baicalin on airway remodeling of bronchial asthma
摘要
Abstract
AIM:To explore the effect and mechanism of baicalin on the airway remodeling of bronchial asthma.METHODS:Animal models of airway remodeling in asthmatic rats were induced by egg albumen (OVA).After the treatment of Baicalin,expressions of TGF-β1,p-ERK1/2 and α-SMA in the lung tissue of rats were detected by immunohistochemical method,and the level of p-ERK1/2 mRNA in the airway smooth muscle (ASM) was detected by RT-PCR.RESULTS:Expressions of pERK1/2,α-SMA and TGF-β1 were significantly increased in the model group,which were all higher than those of dexamethasone group,baicalin high dose group and low dose group (P＜0.05or P ＜0.01).CONCLUSION:Baicalin can decrease the expression of TGF-β1,α-SMA,affect the ERK signal pathways,down regulate the content of p-ERK1/2 mRNA,thereby reducing airway inflammation and delaying airway remodeling.关键词
黄芩苷/气道重塑/ERK信号通路/TGF-β1/α-SMAKey words
baicalin/airway remodeling/ERK signal pathways/TGF-β1/α-SMA分类
医药卫生引用本文复制引用
韩超,杨柳,张秋玲,潘竞锵,徐俊..黄芩苷对哮喘大鼠气道重塑作用的实验研究[J].中国临床药理学与治疗学,2017,22(7):749-754,6.基金项目
广东省中医药局基金项目(20141226) （20141226）
广州市中医药、中西医结合项目(20142A011001) （20142A011001）
