中国临床药理学与治疗学2017，Vol.22Issue(7)：762-766,5.
柚皮苷通过下调p70S6K抑制非小细胞肺癌细胞生长的作用机制研究
Naringin inhibits the growth of non-small cell lung carcinoma cells through down-regulating p70S6K
摘要
Abstract
AIM:To study the effect of naringin on the growth of non-small cell lung carcinoma cells (NSCLC) and its mechanism.METHODS:SRB method was employed to investigate the inhibitory effect of naringin on the growth of non-small cell lung carcinoma cell lines.Western blot was used to detect the pT0S6K expression.The plasmid encoding full length p70S6K was transfected to over-express p70S6K.The small-interfering RNA was used to knockdown p70S6K expression.RESULTS:Naringin inhibited the growth of NSCLC cells,and down-regulated the expression of p70S6K.The overexpression of p70S6K partially abrogated the inhibitory effect of naringin,while knockdown of p70S6K enhanced the effect of naringin.CONCLUSION:Naringin can down-regulate the p70S6K to inhibit the growth of NSCLC cells.关键词
p70S6K/柚皮苷/非小细胞肺癌细胞Key words
p70S6K/naringin/non-small cell lung carcinoma cells分类
医药卫生引用本文复制引用
高中原,孙更,李敏,谌茜,李萍,王雪融..柚皮苷通过下调p70S6K抑制非小细胞肺癌细胞生长的作用机制研究[J].中国临床药理学与治疗学,2017,22(7):762-766,5.基金项目
国家自然科学基金(81473241,81102458,81172004) （81473241,81102458,81172004）
