中国临床药理学与治疗学2017，Vol.22Issue(7)：831-840,10.
Treg细胞抑制基质金属蛋白酶-9对类风湿性关节炎伴急性脑缺血损伤的研究进展
Research on the inhibition of Treg cells on MMP-9 in rheumatoid arthritis with acute cerebral ischemia
摘要
Abstract
Recent studies have found that patients with rheumatoid arthritis (RA) are more likely to suffer from acute cerebral ischemia and other cardiovascular diseases than healthy people.RA further aggravated the development of acute cerebral ischemia.Matrix metalloproteinase-9 (MMP-9) may degrade the extracellular matrix,the damage of bloodbrain barrier,the infiltration of inflammatory cells and pro-inflammatory cytokine.MMP-9 helps to build the series-wound amplifiers of inflammatory cascade reaction after cerebral ischemia.Treg cells can inhibit MMP-9 activity through multiple pathways to control acute cerebral ischemia and alleviate the symptoms of RA.First,Treg cells inhibit the activity of MMP-9 by blocking NF-κB pathway;Second,Treg cells can inhibit MMP-9 by regulating the expression of TGF-β1 and TNF-α;Third,Treg cells transform the polarization type of microglia/macrophage activated by acute cerebral ischemia to prevent MMP-9g secretion and the reinforce the immune tolerance of M2 microglia/macrophages;Fourth,Treg cells release anti-inflammatory cytokines to antagonize Thl7 cells,to regulate immune balance and to alleviate inflammation induced by RA with acute cerebral ischemia.This article reviewed the therapeutic effects of Treg cells in treating RA with acute cerebral ischemia by inhibiting the activity of MMP-9 in hope of providing a reference for the effective treatment and research of RA with acute cerebral ischemia.关键词
类风湿性关节炎/急性脑缺血/调节性T细胞/基质金属蛋白酶-9Key words
rheumatoid arthritis/acute cerebral ischemia/regulatory T cells/matrix metalloprotein-9分类
医药卫生引用本文复制引用
沈忱,李运曼,夏念,徐丹,韩丹,陈仕杰..Treg细胞抑制基质金属蛋白酶-9对类风湿性关节炎伴急性脑缺血损伤的研究进展[J].中国临床药理学与治疗学,2017,22(7):831-840,10.基金项目
产学研联合创新资金-前瞻性联合研究项目的资助(BY2914129) （BY2914129）
