中国临床药学杂志2017，Vol.26Issue(4)：221-225,5.
基于偏最小二乘-判别分析算法的参麦注射剂不良反应关键影响因素分析
Analysis on critical effect factors of adverse drug reaction induced by Shenmai injection based on partial least squares discriminant analysis algorithm
摘要
Abstract
AIM To investigate the critical effect factors of adverse drug reaction (ADR) induced by Shenmai injection by partial least squares discriminant analysis (PLS-DA) algorithm.METHODS The clinical manifestation of patients after using Shenmai injection was monitored.The information of patients and medication was also extracted.Based on the information,the multivariate data matrix was built and the PLS-DA model was then established.The scores plot was applied to investigate the overall differences between the groups experienced ADR and the other without experienced ADR.The variables with most significant variation between 2 groups were screened according to the loading plot.RESULTS The results showed that there was higher risk of ADR for patients who had such characteristics as history of trauma surgery,history of drug allergy,low body weight and advanced age.It was conducive to reducing the risk of ADR by subjecting Shenmai injection with large volume of glucose injection or glucose and sodium chloride injection as dissolvant.CONCLUSION This case study demonstrates that it is effective to employ PLS-DA algorithm for analyzing the critical effect factors of ADR induced by Shenmai injection.This research provides a new scientific tool for the investigation of ADR induced by traditional Chinese medicine injections.关键词
参麦注射剂/药物不良反应/偏最小二乘-判别分析/关键影响因素Key words
Shenmai injection/adverse drug reaction/partial least squares discriminant analysis/critical effect factor引用本文复制引用
蒋程,丁静,孙云峰,何程程,李强,张美玲..基于偏最小二乘-判别分析算法的参麦注射剂不良反应关键影响因素分析[J].中国临床药学杂志,2017,26(4):221-225,5.基金项目
浙江省公益技术应用研究计划项目(编号2016C33127) （编号2016C33127）
浙江省中医药科技计划项目(编号2015ZQ007) （编号2015ZQ007）
浙江省立同德医院科研基金博士科研专项(编号TD2015B004) （编号TD2015B004）
