中国比较医学杂志2017，Vol.27Issue(8)：1-5,5.DOI:10.3969.j.issn.1671-7856.2017.08.001
斑马鱼模型在糖尿病研究中的应用
Application of zebrafish models in research of diabetes
摘要
Abstract
As a model organism, zebrafish have many advantages over other animal models and is suitable for studies on establishment of human disease model and mechanism.In zebrafish, there are two phases of endocrine formation during early development, which are directed by concomitant activity of many signaling pathways.Zebrafish pancreas possess similar cell structure with that of other animals, which can express various endocrine hormones including insulin.The main organs required for metabolic control, such as the pancreas, islet, and insulin sensitive tissue (muscle, liver) are conserved in zebrafish, and the mechanisms of glucose regulation in zebrafish is similar to that seen in mammalian models.These render it an excellent model to study glucose metabolism.Hyperglycemia in zebrafish model can be induced by administration of the diabetogenic drug, streptozotocin (STZ), alternatively immersion of the fish in glucose solution and water, or disturbing of signaling pathways associated with glucose metabolism.Glucose levels in adult zebrafish blood or embryo tissue and phenotype of retinal cell layers or retinal vasculature are the commonly used measurement organs in zebrafish diabetic models.关键词
斑马鱼/糖尿病/模式生物/胰腺/糖代谢Key words
Zebrafish/Diabetes/Model organism/Pancreas/Glucose metabolism分类
医药卫生引用本文复制引用
王雪,韩利文,何秋霞,韩建,王荣春,陈维云,王希敏,侯海荣,刘可春..斑马鱼模型在糖尿病研究中的应用[J].中国比较医学杂志,2017,27(8):1-5,5.基金项目
国家自然科学基金资助项目(31400979) （31400979）
山东省自主创新重大专项(2014ZZCX0215). （2014ZZCX0215）
