中国比较医学杂志2017，Vol.27Issue(8)：12-15,4.DOI:10.3969.j.issn.1671-7856.2017.08.003
2型糖尿病db/db小鼠的生物学特性
Biological characteristics of a db/db mouse model of type 2 diabetes
摘要
Abstract
Objective To observe the biological characteristics of db/db mice, and to provide the basis for application of db/db mice in experimental research.Methods Spontaneous type 2 diabetes BKS.Cg-Dock7m +/+ Leprdb/JNju mice and wild type mice of the same age were used in this study.Their fasting blood glucose was determined at 8,12,16, 20 and 24 weeks of age, the body weight was recorded at 10, 12,16, 20 and 24 weeks of age, the levels of serum insulin, total cholesterol and triglyceride were measured, the organ weight and liver coefficient were determined, and the liver and pancreas were taken for pathological examination at 24 weeks of age.Results The db/db mice maintained a high level of fasting blood glucose and body weight.Levels of serum insulin, total cholesterol, and triglyceride were significantly higher than the wild type mice.Compared with wild type mice, liver weight and kidney weight were also significantly increased.Obvious pathological changes of liver and pancreas were observed in 24-week old db/db mice.Conclusions db/db mouse has obvious characteristics of type 2 diabetes, such as hyperglycemia, hyperlipidemia, and hyperinsulinemia, can maintain stable levels of high blood glucose,and is an ideal animal model for experimental study of type 2 diabetes mellitus.关键词
db/db小鼠/2型糖尿病/生物学特性Key words
db/db mice/Type 2 diabetes/Biological characteristics分类
医药卫生引用本文复制引用
邢玮,王政霖,吕甜甜,王宏亮,袁悦莹,韩静,吴晏..2型糖尿病db/db小鼠的生物学特性[J].中国比较医学杂志,2017,27(8):12-15,4.基金项目
国家自然科学基金(81303083). （81303083）
