中国医学伦理学2017，Vol.30Issue(8)：927-931,5.DOI:10.12026/j.issn.1001-8565.2017.08.01
CRISPR/Cas9基因编辑技术在临床研究中的伦理审查问题探讨
Discussion on Ethical Review Question of CRISPR/Cas9 Gene Editing Technology in Clinical Research
周吉银 1刘丹 1曾圣雅 1周来新2
作者信息
- 1. 第三军医大学新桥医院国家药物临床试验机构,重庆400037
- 2. 第三军医大学新桥医院医教部,重庆400037
- 折叠
摘要
Abstract
Objective:To explore the ethical review questions of CRISPR/Cas9 gene editing technology caused in clinical research,and thus to provide a reference for matters needing attention of the ethical review involved in this technology in clinical.Methods:This paper summarized the ethical problems of CRISPR/Cas9 gene editing technology at home and abroad,analyzed the reasons and put forward some suggestions for the application of new technology in line with China's national conditions.Results:It should allow CRISPR/Cas9 gene editing technology to be applied in somatic cell gene therapy,forbidden for genital gene therapy and not considered to enhance.Since CRISPR/Cas9 lack clear subject of responsibility ethics,it brings security,conflict of rights and social equality issues.The measures that need to be taken include the strengthening of cultural communication,the formation of ethic forms of gene editing technology,the establishment of independent ethical review body at national's level,the improvement of legal norms,the formulating of technical standards and ethical principles and the major support to gene editing research field at the national level.Conclusion:In view of the potential clinical application of CRISPR/Cas9,our country should progressively restrictively develop the embryonic gene editing techniques from the prohibition.The ethics committee is responsible for the ethical review and supervision of clinical research.Members of the ethics committee and ethical staff should strengthen the study of new knowledge,strictly docking policies and regulations from accepting the clinical research projects involving CRISPR / Cas9 to ethical review,and thus to ensure the effectively review the ethical problems of genetic editing technology project.关键词
CRISPR/Cas9基因编辑技术/临床研究/伦理审查Key words
CRISPR/Cas9 Gene Editing Technology/Clinical Research/Ethical Review分类
医药卫生引用本文复制引用
周吉银,刘丹,曾圣雅,周来新..CRISPR/Cas9基因编辑技术在临床研究中的伦理审查问题探讨[J].中国医学伦理学,2017,30(8):927-931,5.
