中华骨质疏松和骨矿盐疾病杂志2017，Vol.10Issue(4)：406-410,5.DOI:10.3969/j.issn.1674-2591.2017.04.017
抗凝药物相关骨质疏松症
Anticoagulant drugs and osteoporosis
张翔 1张嘉1
作者信息
- 1. 100730北京,中国医学科学院北京协和医学院北京协和医院骨科
- 折叠
摘要
Abstract
Long-term use of anticoagulant drugs are indicated to be correlated with an increased risk of osteoporosis.Vitamin K antagonists and direct/indirect thrombin inhibitors are listed in popularity for treatment and thromboprophylaxis.Cumulative clinical outcomes reported that bone loss with fractures also occu~ in severe ca~s.These drugs may affect bone turnover and result in bone loss far exceeding the bone formation.New oral anticoagulant drugs,low molecular weight heparin and fondaparinux are novel therapeutic options due to rare side effects on bone health.In the present paper,we reviewed the association between anticoagulant drugs and osteoporosis,as well as its underlying possible mechanisms.关键词
抗凝药物/骨质疏松症/骨质疏松性骨折/不良反应Key words
anticoagulant drugs/osteoporosis/osteoporotic fractures/side effects分类
医药卫生引用本文复制引用
张翔,张嘉..抗凝药物相关骨质疏松症[J].中华骨质疏松和骨矿盐疾病杂志,2017,10(4):406-410,5.
