浙江医学2017，Vol.39Issue(13)：1068-1071,4.DOI:10.12056/j.issn.1006-2785.2017.39.13.2016-1352
Rs4129009基因多态性与慢性HBV感染的相关性研究
Association of TLR10 Rs4129009 gene polymorphism with chronic hepatitis B virus infection
摘要
Abstract
Objective To investigate the relationship between the gene polymorphism of Toll like receptor 10 (TLR10) and chronic HBV infection.Methods The peripheral blood samples from 428 chronic HBV infected patients and 210 healthy controls were collected.The extracted whole genome DNA was specifically amplified by polymerase chain reaction (PCR).Then,direct sequencing was performed.Results The characteristics of two groups were in accordence with Hardy-Weinberg balance (both P ＞0.05).The frequency of AG+GG genotypes and G allele in HBV infected group were lower than those in healthy control (P＜0.01).The subgroup analysis demonstrated that variant gene in HBVDNA ＞ 1061U/ml group and HBeAg positive group were higher than the other groups (P＜0.01),nevertheless,no significant difference were found in the subgroups of the severity of HBV infection and family medical history (P ＞0.05).Conclusion Polimorphism of Rs4129009 in TLR10 may be related to chronic HBV infection.关键词
Toll样受体10/基因多态性/乙型肝炎病毒Key words
Toll like receptor 10/Polymorphism/Hepatitis B virus引用本文复制引用
汤永志,陈巧玲,江挺,朱敏,燕飞,陈华忠,朱坚胜..Rs4129009基因多态性与慢性HBV感染的相关性研究[J].浙江医学,2017,39(13):1068-1071,4.基金项目
台州市科技计划项目(20111ky0604) （20111ky0604）
