浙江医学2017，Vol.39Issue(13)：1084-1087,4.DOI:10.12056/j.issn.1006-2785.2017.39.13.2017-688
腹膜透析对慢性肾脏病患者脂联素水平、微炎症及营养状态的影响
Micro-inflammation and nutritional status of patients with chronic kidney disease undergoing peritoneal dialysis
林建 1叶晴 1詹林达 1菅宏蕴1
作者信息
- 1. 528403 广东省中山市人民医院肾内科
- 折叠
摘要
Abstract
Objective To investigate the micro-inflammation and nutritional status in patients with chronic kidney disease (CKD) undergoing peritoneal dialysis.Methods Sixty two patients with CKD attending in our hospital from September 2011 to August 2016 were randomly divided into two groups with 31 in each group.Patients in the control group received hemodialysis,while patients in study group received peritoneal dialysis.Serum adiponectin (ADPN),CRP and IL-6 levels were measured by enzyme linked immunosorbent assay (ELISA) after first dialysis,and 1 months,3 months and 6 months after dialysis.The nutritional status of patients was evaluated by malnutrition-inflammation score (MIS).The quality of life of patients was evaluated by the Kidney Disease Quality of Life-Short Form (KDQOL-SF).Results There were no significant differences in serum ADPN,CRP and IL-6 before dialysis between two groups (P ＞0.05).After dialysis treatment,the serum ADPN,CRP and IL-6 showed an upward trends in both groups with the time prolonging (P＜0.05),however,the levels in study group were significantly lower than those in control group at each time points (P＜0.05).After 6 months of dialysis,the malnutrition rate in study group was significantly lower than that in control group (P＜0.05).The quality of live scores in study group were significantly higher than those in control group (P＜0.05).Conclusion Compared with hemodialysis,peritoneal dialysis can more significantly reduce malnutrition and improve the nutritional status and quality of live in CKD patients,which is associated with the reduction of inflammatory factors and ADPN levels.关键词
腹膜透析/慢性肾脏病/ADPN/CRP/IL-6/营养不良Key words
Peritoneal dialysis/Chronic kidney disease/Adiponectin/C-reactive protein/Interleukin-6/Malnutrition引用本文复制引用
林建,叶晴,詹林达,菅宏蕴..腹膜透析对慢性肾脏病患者脂联素水平、微炎症及营养状态的影响[J].浙江医学,2017,39(13):1084-1087,4.
