浙江医学2017，Vol.39Issue(14)：1158-1161,4.DOI:10.12056/j.issn.1006-2785.2017.39.14.2017-905
金华地区慢性乙型肝炎患者HBV基因型及耐药基因位点突变类型分析
Genotypes and mutation patterns of HBV gene in chronic hepatitis B patients in Jinhua
摘要
Abstract
Objective To analyze genotypes and mutation patterns of HBV gene in chronic hepatitis B patients in Jinhua.Methods One hundred and four patients with chronic hepatitis B who were treated with nucleoside analogues,were enrolled in the study.Sanger sequence analysis of HBV genotypes and 10 common sites of HBV P region were performed.Results There were 46.15％ cases of B genotype and 53.85％ of C genotype among 104 chronic hepatitis B patients.Other genotypes were no detected.HBV P gene mutation were detected in 61 cases (58.65％);there was 65.57％ in HBV C genotype and 34.43％ in B genotype.M204V/I was the most common site of HBV P gene mutation (73.85％),followed by L180M (36.92％) and A181V/T (23.08％).50.82％ cases had single site mutation and the most mutation pattern was M204I (29.51％);and 49.18％ had multiple sites mutation;the most common mutation patterns were M204I and M204V/I+L180M.The resistance mutation rate in C genotype was higher than that in B genotype(71.43％ vs 43.75％,P＜0.05) and the mutation rate of A181V/T in C genotype cases was higher than that in B genotype cases (14.29％ vs 2.08％,P＜0.05).Conclusion Genotype B and C are the main genotypes of HBV in this study.The most common mutation patterns of HBV P gene were M204I and M204V/I+L180M.Genotype C patients had more mutations than genotype B and the A181V/T mutation pattern was more common in genotype C.关键词
慢性乙型肝炎/耐药突变/基因型/核苷(酸)类似物Key words
Chronic hepatitis B/Resistance mutation/Genotype/Nucleoside analogues引用本文复制引用
刘颖,朱以军,王月..金华地区慢性乙型肝炎患者HBV基因型及耐药基因位点突变类型分析[J].浙江医学,2017,39(14):1158-1161,4.
