浙江医学2017，Vol.39Issue(14)：1195-1197,1215,4.DOI:10.12056/j.issn.1006-2785.2017.39.14.2017-51
恶性肿瘤合并HBV感染患者化疗后HBV再激活及相关高危因素分析
Risk factors of HBV reactivation in HBV-infected patients with malignant tumor undergoing chemotherapy
周建伟 1林介军 1张慧 1朱方超 1黄智铭2
作者信息
- 1. 325000 温州医科大学定理临床学院/温州市中心医院消化内科
- 2. 温州医科大学附属第一医院消化内科
- 折叠
摘要
Abstract
Objective To investigate the risk factors of HBV reactivation in HBV-infected patients with malignant neoplasms undergoing chemotherapy.Methods Seventy eight patients with malignant tumors undergoing chemotherapy,including 34 patients with positive HBsAg (study group) and 44 patients with negative HBsAg (control group),were enrolled in the study.The reactivation of HBV during chemotherapy was observed;the liver function indicators were measured before and after treatment and compared between two groups.The risk factors related to HBV reactivation were analyzed.Results HBV reactivation occurred in9 cases (26.47％) of study group.The incidence of liver injury after chemotherapy was 52.94％ (18/34),which was higher than that of control group(29.55％,13/44),the difference was statistically significant(P＜0.05).The administration of glucocorticoids and anthracycline drugs was a risk factor of HBV re-activation in HbsAg-positive patients.Conclusion Liver damage during chemotherapy is more serious in cancer patients with HBV infection,and the use of steroids and anthracyclinesincreased the risk of HBV reactivation in those patients.关键词
恶性肿瘤/化疗/再激活Key words
Malignant neoplasms/Chemotherapy/Reactivate引用本文复制引用
周建伟,林介军,张慧,朱方超,黄智铭..恶性肿瘤合并HBV感染患者化疗后HBV再激活及相关高危因素分析[J].浙江医学,2017,39(14):1195-1197,1215,4.
