中国中西医结合杂志2017，Vol.37Issue(8)：991-995,5.DOI:10.7661/j.cjim.20170614.135
3.0T磁共振质子波谱成像评价吉西他滨联合黄芪多糖注射液治疗胰腺癌模型兔的研究
Treatment of Pancreatic Cancer Model Rabbits by Docetaxel Combined with Astragalus Polysaccharide Injection Evaluated by 3.0T Proton Magnetic Resonance Spectroscopy
摘要
Abstract
Objective To observe the evaluation of 3.0T magnetic resonance spectroscopy imaging (1H MRS) for clinical efficacy of treating pancreatic cancer by docetaxel combined with Astragalus Polysaccharide Injection (API).Methods Recruited were 60 rabbits in which pancreatic cancer model were successfully prepared.Then they were divided into treatment group 1,treatment group 2,and the control group by random number table,20 in each group.Rabbits in treatment group 1 were injected with docetaxel and API from tail vein.Rabbits in treatment group 2 were injected with gemcitabine from tail vein.Rabbits in the control group were injected with equal volume of normal saline.All rabbits were treated for 2 weeks.Rabbits received 3.0T magnetic resonance proton spectroscopy at the same time.Proton spectroscopy sequence (PRESS) was discriminated by selecting singular point.The performance of metabolites in spectral imaging was analyzed.(Chol +Unsat/Lip) of the mixed peak of cholesterol and unsaturated fatty acids (Chol + Unsat) and the peak of fat (LIP) were calculated and compared among the three groups.Results The main metabolic peaks in the magnetic resonance proton spectroscopy of the three groups mainly included Lip peak,Chol + Unsat peak and choline (Cho) peak.There was no significant difference in Cho peak rate among the three groups (P＞0.05).The mean value of (Chol + Unsat)/Lip was (0.316±0.125) in the control group,(0.224 ±0.095) in treatment group 1,and (0.267±0.101) in treatment group 2.Statistical difference existed between treatment group 1/2 and the control group (P ＜0.05) as well as between treatment group 1 and treatment group 2 (P＜0.05).Conclusions Gemcitabine combined with API had favorable curative effect on pancreatic cancer.The therapeutic effect on pancreatic cancer model could be evaluated by performance of metabolite using 3.0T magnetic resonance proton spectroscopy.关键词
磁共振质子波谱成像/吉西他滨/黄芪多糖注射液/胰腺癌Key words
proton magnetic resonance spectroscopy/gemcitabine/Astragalus Polysaccharide Injection/pancreatic cancer引用本文复制引用
郝利国,张淑丽,崔红升,杨艳丹,张广凤,梁明辉,陈大同..3.0T磁共振质子波谱成像评价吉西他滨联合黄芪多糖注射液治疗胰腺癌模型兔的研究[J].中国中西医结合杂志,2017,37(8):991-995,5.基金项目
黑龙江中医药中青年科技攻关项目(No.ZQG-077) （No.ZQG-077）
齐齐哈尔医学院院内科研基金资助项目(No.QY2016M-06) （No.QY2016M-06）
