重庆医学2017，Vol.46Issue(24)：3336-3338,3342,4.DOI:10.3969/j.issn.1671-8348.2017.24.007
右美托咪定对体外循环心脏瓣膜置换患者术后肾功能的影响
Effects of dexmedetomidine on postoperative renal function in patients undergoingcardiac valve replacement under cardiopulmonary bypass
摘要
Abstract
Objective To investigate the effect of dexmedetomidine on renal function in the patients undergoing cardiac valve replacement under cardiopulmonary bypass.Methods Fifty patients with rheumatic heart disease were randomly divided into the dexmedetomidine group (group D,n=25) and control group (group C,n=25).Arterial blood samples were collected before operation (T0),at postoperative 24 h (T1),48 h (T2),72 h (T3) and 96 h (T4) respectively.Serum Crea,blood urea nitrogen,cystatin C(Cys-C) and glomerular filtration rate(GFR) were detected by the Hitachi7600 automatic biochemical analyzer.Results Compared with T0,the levels of BUN and Cys-C at postoperative various time points were significant increased,while GFR was decreased,the differences were statistically significant (P<0.05).The levels of BUN and Cys-C started to gradually decrease and GFR started to increase from T2,the difference compared with that at T0 was statistically significant(P<0.05).But the levels of various indicators at T4 did not recovered to those before operation;compared with T0,serum Crea level had no statistical difference among postoperative various time points(P>0.05).Serum Crea level at T2-T4 in the group D was significantly lower than that at T0,the difference was statistically significant (P<0.05).There was no statistically significant difference in Crea,BUN,Cys-C and GFR between the two groups(P>0.05).Conclusion Dexmedetomidine can promote the recovery of postoperative renal function in the patients with cardiac valve replacement under cardiopulmonary bypass and has a certain protective effect on kidney.关键词
体外循环/风湿性心脏病/肾功能试验/麻醉,全身/右美托咪定Key words
extracorporeal circulation/rheumatic heart disease/kidney function tests/anesthesia/general/dexmedetomidine分类
医药卫生引用本文复制引用
王晓军,施燕飞,徐连生,张红..右美托咪定对体外循环心脏瓣膜置换患者术后肾功能的影响[J].重庆医学,2017,46(24):3336-3338,3342,4.基金项目
四川省卫计委资助项目资助项目(110601) （110601）
四川省宜宾市科技局基金资助项目(2014SF015). （2014SF015）
