动物营养学报2017，Vol.29Issue(3)：749-754,6.DOI:10.3969/j.issn.1006-267x.2017.03.003
氨基酸缺乏诱导细胞自噬的哺乳动物雷帕霉素靶蛋白复合体C1信号通路机制研究进展
Advances in Lack of Amino Acid-Mediated Autophagy via Mammalian Target of Rapamycin Complex 1 Signal Pathway
摘要
Abstract
Autophagy is an important physiological activity for keeping organism steady.Cell will active the autophagy when the nutrient as amino acid and glucose deficiency.The autophagy is regulated by many signal pathways,and mammalian target of rapamycin complex 1 (mTORC1) is one of the important pathway,it can make autophagy factor autophagy-related gene 13 (Atg13) phosphorylation to inhibit autophagy starting.In this review,we summarized the results and conclusions from recent works on amino acid-mediated autophagy via the mTORC1 signal pathway including small G protein,adenosine 5 monophosphate-activated protein kinase (AMPK),microRNA (miRNA) and aminoacyl-tRNA synthetase.关键词
氨基酸/自噬/mTORC1/机制Key words
amino acid/autophagy/mTORC1/mechanism分类
农业科技引用本文复制引用
柏雪,王建萍,丁雪梅,白世平,曾秋凤,张克英..氨基酸缺乏诱导细胞自噬的哺乳动物雷帕霉素靶蛋白复合体C1信号通路机制研究进展[J].动物营养学报,2017,29(3):749-754,6.基金项目
国家自然科学基金青年项目(31402031) （31402031）
四川省教育厅青年基金(13ZB0290) （13ZB0290）
科技部支撑计划(2014BAD13B04) （2014BAD13B04）
四川省科技厅项目(2014NZ0043,2014NZ0002,2013NZ0054) （2014NZ0043,2014NZ0002,2013NZ0054）
