高等学校化学学报2017，Vol.38Issue(8)：1375-1382,8.DOI:10.7503/cjcu20170024
(Z)-3,3-二甲基-1-(1H-1,2,4-三唑-1-基)-2-丁酮肟(5-芳基-1,3,4-噁二唑-2-基)甲基醚的合成和抑菌活性
Synthesis, Crystal Structure and Fungicidal Activity of (Z)-3,3-Dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one O-[(5-Aryl-1,3,4-oxadiazol-2-yl)methyl]oxime
摘要
Abstract
A series of (Z)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one O-[(5-aryl-1,3,4-oxadiazol-2-yl)methyl]oxime(4a-4u) was designed and synthesized via the reaction between iodobenzene diacetate(IBD) and the intermediates, (E)-N′-substituted benzylidene-2-({(Z)-[3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ylidene]amino}oxy)acetohydrazide(3), which were prepared from (Z)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one oxime via etherification, hydrazinolysis and condensation with various of substituted benzaldehyde.The structures of target compounds 4 were confirmed by muclear magnetian resonance(NMR), high resolution mass spectrum(HRMS) and elemental analysis.The crystal structure of compound 4c was determined by X-ray diffraction analysis.The results of fungicidal activity indicated that some of the title compounds exhibited moderate control rate against Rhizoctonia solani at 500 mg/L and moderate inhibition rate against Sclerotonia sclerotiorum at 25 mg/L.关键词
1,3,4-噁二唑/二乙酸碘苯/单晶结构/抑菌活性Key words
1/3/4-Oxadiazole/Iodobenzene diacetate/Single-crystal structure/Fungicidal activity分类
化学化工引用本文复制引用
谭英,肖梦武,叶姣,胡艾希,曾子清,欧晓明..(Z)-3,3-二甲基-1-(1H-1,2,4-三唑-1-基)-2-丁酮肟(5-芳基-1,3,4-噁二唑-2-基)甲基醚的合成和抑菌活性[J].高等学校化学学报,2017,38(8):1375-1382,8.基金项目
长沙市科技计划项目(批准号: Kq1602039)资助.Supported by the Science and Technology Program of Changsha, China(No.Kq1602039). （批准号: Kq1602039）
