临床与病理杂志2017，Vol.37Issue(8)：1553-1559,7.DOI:10.3978/j.issn.2095-6959.2017.08.001
复方中草药对缓解大气细颗粒物致呼吸系统损伤的影响
Effect of Chinese herbal medicine on respiratory system injury caused by air fine partic1es
摘要
Abstract
Objective: To evaluate the effect of Chinese herbal medicine for alleviating the respiratory system injury caused by air pollution, and the effect of compound Chinese herbal medicine on the respiratory system injury caused by air fine particles was studied. Methods: The atmospheric PM2.5 samples were collected from Changsha City traffic area during the winter. The mouse of C57BIV6 was used as the test object feeding this herbal medicine (a total of 8 kinds of herbal ingredients). When the mice exposed in air pollution, the effects on the functions of the respiratory tract and lung pathology were observed. Results: The respiratory function indexes of experimental mice, such as cough latent period, cough frequency and excretion of phenolsulfonphthalein were observed. The lung tissue pathological indexes, such as pulmonary congestion, bronchial epithelial high column, small artery wall thickening, pulmonary hemorrhage, alveolar septal thickening, tissue necrosis, fibrous tissue proliferation and Langerhanscell (LC) proliferation were also observed. The results showed that respiratory function was obviously weakened caused by air fine particles, pathology changes significantly. The compound Chinese herbal medicine was quite effective to the respiratory system injury caused by air fine particles. Conclusion: Air fine particles can cause many kinds of lung tissue lesions with different degree. The compound Chinese herbal medicine has better protective effect on lung lesions caused by air fine particles.关键词
复方中草药/大气细颗粒物/缓解/呼吸系统损伤Key words
Chinese herbal medicine/air pollution/relieve/respiratory system damage引用本文复制引用
金岚,吴尚洁..复方中草药对缓解大气细颗粒物致呼吸系统损伤的影响[J].临床与病理杂志,2017,37(8):1553-1559,7.基金项目
国家重大科技基金(2013BAI09B14).This work was supported by National Science and Technology Ministry, China (2013BAI09B14). （2013BAI09B14）
