临床与病理杂志2017，Vol.37Issue(8)：1565-1570,6.DOI:10.3978/j.issn.2095-6959.2017.08.003
黄连素对实验性子宫肌瘤大鼠的作用及相关机制
Effects and mechanisms of berberine on hysteromyoma in rats
黄亚哲 1安爱平 1陈建玲 1王丽蕊 2王秋宇 3李晓翔 3祁彦萍3
作者信息
- 1. 南阳市中心医院生殖医学科,河南 南阳 473000
- 2. 河北省围场县医院妇产科,河北 围场 0684501
- 3. 南阳市中心医院妇产科,河南 南阳 473000
- 折叠
摘要
Abstract
Objective: To investigate the effects and mechanisms of berberine on hysteromyoma in rats. Methods:Hysteromyoma model was established in rats. Then the levels of IFN-α and TNF-α were analyzed by ELISA assay. Blood viscosity and hysteromyoma coefficient were examined. The morphological changes in uterus were observed using HE staining. The expressions of ER-α and Bcl-2 in uterine smooth muscle cells were detected by immunohistochemistry. Results: After Berberine administration, IFN-α levels significantly increased, while TNF-α levels decreased. Moreover, berberine treatment decreased whole blood viscosity, plasma viscosity and erythrocyte aggregation index, while reduced hysteromyoma coefficient and inflammatory cells infiltration, and inhibited ER-α and Bcl-2 expressions in uterine smooth muscle cells. Conclusion: Berberine can improve hysteromyoma in rats, which may be likely through regulation of the levels of inflammatory factors and bcl-2.关键词
子宫肌瘤/黄连素/炎性因子/bcl-2Key words
hysteromyoma/berberine/inflammatory factors/bcl-2引用本文复制引用
黄亚哲,安爱平,陈建玲,王丽蕊,王秋宇,李晓翔,祁彦萍..黄连素对实验性子宫肌瘤大鼠的作用及相关机制[J].临床与病理杂志,2017,37(8):1565-1570,6.
