临床与病理杂志2017，Vol.37Issue(8)：1583-1586,4.DOI:10.3978/j.issn.2095-6959.2017.08.006
非小细胞肺癌患者胸腔积液中EGFR基因突变的检测及临床意义
Detection of EGFR mutations and its c1inica1 significance in hydrothorax of patients with non-small cell lung cancer
摘要
Abstract
Objective: To explore the clinical significance of detecting epidermal growth factor receptor (EGFR) mutations in hydrothorax of patients with non-small cell lung cancer (NSCLC). Methods: The mutations of EGFR in exon 18-21 were detected with Sanger sequencing in 17 hydrothorax samples and 17 tumor tissue samples in parallel from patients with NSCLC. Results: There were 5 cases (29.41％) with EGFR mutations in 17 hydrothorax samples and 7 cases (41.18％) in 17 tumor tissue samples. The detection rate of EGFR mutations in hydrothorax samples was lower than that in tumor tissue samples. Conclusion: The hydrothorax sample can be used to detecting EGFR mutations by Sanger sequencing. And it is helpful to patients with NSCLC who can't obtain tumor tissue.关键词
非小细胞肺癌/胸腔积液/EGFR基因Key words
non-small cell lung cancer/hydrothorax/epidermal growth factor receptor引用本文复制引用
毛旭华,汤俊明,乔国洪,陈霞..非小细胞肺癌患者胸腔积液中EGFR基因突变的检测及临床意义[J].临床与病理杂志,2017,37(8):1583-1586,4.基金项目
无锡市卫计委面上项目 (MS201536).This work was supported by Science and Technology Projects of Wuxi City, China (MS201536). （MS201536）
