临床与病理杂志2017，Vol.37Issue(8)：1593-1600,8.DOI:10.3978/j.issn.2095-6959.2017.08.008
肝癌微血管密度、微血管面积和Piezo1的表达与微血管侵犯的相关性
Correlation between microvascular density, microvascular area, Piezo1 expression and microvascular invasion in hepatocellular carcinoma
摘要
Abstract
Objective: To investigate the clinical value of microvascular density (MVD), microvascular area (MVA) and the expression of Piezo1 in predicting microvascular invasion (MVI) of hepatocellular carcinoma (HCC). Methods: Immunohistochemical method was applied to detect the expression of CD34 and Piezo1 of 38 pathologically confirmed HCC for 38 patients, MVD and MVA were measured based on CD34 staining. The correlations between the expression level of Piezo1, MVD, MVA and MVI were analyzed. Results: Thirteen in 38 cases were presented with MVI, defined as MVI (+) group, 25 in 38 cases were absence of MVI, defined as MVI (?) group. The MVA and MVD were significantly higher in MVI (+) group (P=0.007, P=0.011; respectively) than in MVI (?) group. MVD combined with MVA achieved a sensitivity of 100％ and a specificity of 64％ in predicting MVI of HCC, which was higher than single index. The expression level of Piezo1 was significantly higher in the MVI (+) group than in the MVI (?) group (P=0.032). Conclusion: MVD, MVA and the expression level of Piezo1 are significantly correlated with MVI which can be used as surrogate markers of MVI, Piezo1 may be a novel therapy target for restraining MVI.关键词
肝癌/微血管侵犯/微血管密度/微血管面积/Piezo1Key words
hepatocellular carcinoma/microvascular invasion/microvascular density/microvascular area/Piezo1引用本文复制引用
赵伟,李文政,刘文广,刘华平,侯佳乐,冯德云,易小平,裴贻刚,刘慧,刘丽愉..肝癌微血管密度、微血管面积和Piezo1的表达与微血管侵犯的相关性[J].临床与病理杂志,2017,37(8):1593-1600,8.基金项目
中南大学湘雅医院临床科研基金 (2014L05).This work was supported by the Funds for Clinical Research Fund of Xiangya Hospital of Central South University, China (2014L05). （2014L05）
