国际病理科学与临床杂志2017，Vol.37Issue(8)：1601-1607,7.DOI:10.3978/j.issn.2095-6959.2017.08.009
儿童系统性红斑狼疮患者外周血淋巴细胞表面CD95的表达及临床意义
Expression and significance of CD95 in periphera1 b1ood lymphocytes of children with new-onset systemic lupus erythematosus
石海涛 1张春莲1
作者信息
- 1. 北京儿童医院顺义妇儿医院皮肤性病科,北京 101300
- 折叠
摘要
Abstract
Objective: To investigate the expression of CD95 in peripheral blood lymphocytes of children with systemic lupus erythematosus (SLE) and its relationship with disease activity and other immunological parameters. Methods: Flow cytometry was used to detect the expression of CD95 on T and B lymphocytes in peripheral blood of 60 children with SLE and 20 healthy children, and analyze the relationship between the expression of CD95 and disease activity. Results: The expression of CD95 in CD4+ T cells in peripheral blood of children with SLE was significantly higher than that of healthy children. The expression of CD95 in CD19+ B in peripheral blood of children with SLE was significantly higher than that of healthy children. The proportion of CD4+ CD95+ T cells was positively correlated with SLE disease activity. The proportion of CD19+ CD95+ B cells was positively correlated with SLE disease activity. The proportion of CD4+ CD95+ T cells was positively correlated with the level of anti-double stranded DNA antibody (anti-dsDNA Abs) in peripheral blood. Conclusion: The expression level of CD95 in peripheral blood lymphocytes of children with SLE is significantly increased, and the activity of SLE is correlated with the activity of SLE and anti-double stranded DNA antibody in serum.关键词
儿童/系统性红斑狼疮/T淋巴细胞/B淋巴细胞/CD95Key words
children/systemic lupus erythematosus/T lymphocytes/B lymphocytes/CD95引用本文复制引用
石海涛,张春莲..儿童系统性红斑狼疮患者外周血淋巴细胞表面CD95的表达及临床意义[J].国际病理科学与临床杂志,2017,37(8):1601-1607,7.
