内科理论与实践2017，Vol.12Issue(3)：180-185,6.DOI:10.16138/j.1673-6087.2017.03.008
预激方案和标准方案治疗初治急性髓系白血病的临床观察
A comparison between priming induction regimen and standard chemical therapy in treatment of de novo acute myeloid leukemia
摘要
Abstract
Objective To compare the efficacy,side effects and survival between priming induction regimen and standard chemical therapy in de novo patients with acute myeloid leukemia (AML).Methods There were 175 de novo AML patients included in this study:115 patients were treated with standard induction regimen (IA/DA,idarubicin and cytarabine/daunorubicin and cytarabine);60 patients were treated with priming induction regimen (CAG/IAG,cytarabine,aclarubicin and granulocyte colony-stimulating factor/idarubicin,cytarabine and granulocyte colony-stimulating factor).After reaching complete remission (CR) with one or two course of induction chemotherapy,the patients in the two groups received the respective same regimen as induction chemotherapy for consolidation followed by maintenance therapy.Results There were no significant differences in the rate of CR and overall response,disease free survival and overall survival between the two groups (all P＞0.05).But the recovery time of bone marrow,incidence of infection and platelet transfusion in priming induction group was significantly shorter or lower than that in standard chemical therapy group (all P＜ 0.05).Conclusions Our study suggested that the priming induction regimen was similar to standard chemical therapy in treatment efficacy and survival.But the adverse effects,including myelosuppression and infection,were mild in priming induction regimen.Therefore,the priming induction regimen can be considered as the alternative therapy regimens for de novo AML patients.关键词
预激方案/标准方案/急性髓系白血病/初治Key words
Priming induction regimen/Standard chemical therapy/Acute myeloid leukemia/De novo分类
医药卫生引用本文复制引用
朱坚轶,路莎莎,陈芳源,蔡佳翌,韩晓凤,黄洪晖,钟华,钟璐..预激方案和标准方案治疗初治急性髓系白血病的临床观察[J].内科理论与实践,2017,12(3):180-185,6.基金项目
国家自然科学基金项目(项目编号:81470312) （项目编号:81470312）
上海市科学技术委员会科研计划项目(项目编号:14411950704) （项目编号:14411950704）
上海市卫生和计划生育委员会科研课题(项目编号:201440369) （项目编号:201440369）
