现代检验医学杂志2017，Vol.32Issue(4)：32-35,4.DOI:10.3969/j.issn.1671-7414.2017.04.009
体检人群血清胃蛋白酶原、胃泌素-17与幽门螺杆菌抗体分型检测临床分析
Clinical Analysis of Serum Pepsinogen, Gastrin-17 and Helicobacter Pylori Antibody Typing in Physical Examination
摘要
Abstract
Objective To investigate the infection status of Helicobacterpylori (HP) in the physical examination population and the contents of pepsinogen Ⅰ (PGⅠ),pepsinogen Ⅱ (PGⅡ) and gastrin-17 (G-17) in serumand the association with HP infection.Methods In this study,781 cases of physical examination were included.Serum HP antibody typing,PGl,PGⅡ and G-17 were measured by Helicobacter pylori antibody kit and enzyme-linked immunosorbent assay.The levels of PGⅠ,PGⅡ,PGⅠ/PGⅡ and G-17 were analyzed by SPSS22.0 analysis system,and the difference of HP infection rate between HP infection group and non-infected patients and different types of infection was analyzed.Analysis of the infection rate and the difference of each age group.Results There was no significant difference between the two groups (x2 =0.284,P=0.594),and there was significant difference between different age groups (x2 =8.523,P=0.014).The levels of PGⅠ,PGⅡ,PGR and G-17 in serum were statistically significant (Z=8.616～ 14.125,P=0.000) compared with those of HP positive and negative.There were significant differences in serum PGⅡ and PGR levels between HP Ⅰ type and HP Ⅱ type infection (Z=3.444,3.385,P=0.001).The levels of PGⅠ and PGⅡ in serum were significantly higher than those in other groups (Z=5.012,4.478,P=0.000).PGⅠ and PGⅡ were higher in women than in females (Z=0.444～0.941,P＞0.05),with the increase of age,PGⅠ,PGⅡ and G-17 has an upward trend,while PGR showed a downward trend.Conclusion The level of serum PG was closely related to gender,age and HP infection,and was closely related to HP infection classification.The combination of HP antibody typing and serum PG and G-17 as a routine test of gastric function is of great significance in the screening and evaluation of early gastric diseases.关键词
幽门螺杆菌/胃蛋白酶原/胃泌素-17Key words
Helicobacter pylori/pepsinogen/gastrin-17分类
医药卫生引用本文复制引用
张培莉,刘义庆,张炳昌,王勇,邵婧,范卫华..体检人群血清胃蛋白酶原、胃泌素-17与幽门螺杆菌抗体分型检测临床分析[J].现代检验医学杂志,2017,32(4):32-35,4.基金项目
山东省自然科学基金(ZR2016HM52) （ZR2016HM52）
山东省临床重点专科项目(鲁卫医字[2013]26号) （鲁卫医字[2013]26号）
山东省医药卫生重点实验室(鲁卫科教国合字[2013]49号). （鲁卫科教国合字[2013]49号）
