现代检验医学杂志2017，Vol.32Issue(4)：43-46,4.DOI:10.3969/j.issn.1671-7414.2017.04.012
血清维生素B12及同型半胱氨酸检测在脊髓亚急性联合变性中的诊断价值
Diagnostic Value of Detecting Plasma Vitamin B12 and Homocysteine Subacute Combined Degeneration of the Spinal Cord
摘要
Abstract
Objective To discuss the diagnostic value of detecting plasma vitamin B12 and Homocysteine (Hcy) in subacute combined degeneration of the spinal cord (SCD).Methods Parents of SCD (n=29) and subjects (n=74) without spinal cord diseases were enrolled from the clinic of Shaanxi Provincial People's Hospital from April 2014 to July 2016.The plasma vitamin B12 and Hcy concentrations were detected using Chemiluminescence Immunoassay (CLIA) and enzyme-linked immuno sorbent assay (ELISA) respectively,and compared using chi-square between the SCD and control groups.Sensitivity rate,specific rate,and diagnose accordance rate were evaluated.Results The plasma homocysteine and vitamin B12 concentrations in SCD and control groups were 49.41 μmol/L vs 12.36 μmol/L,44.35 pg/ml vs 166.75 pg/ml,with significant differences (U=343.50,800.00,P＜0.05).Negative correlation existed between the concentrations of vitamin B12 and Hey (r=-0.248,P=0.012).The sensitivity rates of vitamin B12 and Hcy detections were 55.2％ vs 89.7％,which had significant differences (x2 =8.631,P=0.003),and the diagnose accordance rate (69.9％ vs 64.1％) of the former was higher (x2 =4.175,P=0.041).Conclusion The plasma Hcy and vitamin B12 concentration detections had definite diagnostic value in SCD,and Hcy had higher sensitive rate,which can improve the diagnostic rate of SCD in the early stage.关键词
脊髓亚急性联合变性/血清维生素B12/血清同型半胱氨酸Key words
subacute combined degeneration of the spinal cord/vitamin B12/homocysteine分类
医药卫生引用本文复制引用
张欣,刘西玲,刘玥..血清维生素B12及同型半胱氨酸检测在脊髓亚急性联合变性中的诊断价值[J].现代检验医学杂志,2017,32(4):43-46,4.基金项目
陕西省自然科学基础研究计划项目(S2016YFJM1489). （S2016YFJM1489）
