现代检验医学杂志2017，Vol.32Issue(4)：122-124,3.DOI:10.3969/j.issn.1671-7414.2017.04.035
寻常型天疱疮患者血清HSV,CMV和EBV抗体IgG检测的临床意义
Clinical Significance of the Levels of IgG Antibodies Against HSV,CMV and EBV in Patients' Serum with Pemphigus Vulgaris
摘要
Abstract
Objective To regard the implication of viruses particularly herpes in pemphigus vulgaris,and assess and compare the level of immunoglobulin G (IgG) antibodies against herpes simplex virus types 1 and 2 (HSV1 and HSV2),cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in patients with pemphigus vulgarisand healthy people.Methods In this study,23 patients with pemphigus vulgaris and 26 healthy individuals comprised the experimental and control groups,respectively.Serum samples were taken from both groups;the levels of IgG antibodies against HSV1,HSV2,CMV and EBV were measured using ELISA.Results Immunoglobulin G titer was higher for all four viruses in the patient group in comparison to the control group.This difference was significant for anti-EBV,anti-CMV and anti-HSV2 (t=2.16,P＜0.05;t =4.76,P＜ 0.01;t=3.75,P＜0.01),respectively,but not significant for anti-HSV1 (t=0.52,P＞0.05).Conclusion Viruses including EBV,CMV,and HSV2 probably play a role in the pathogenesis of pemphigus in addition to the effects of genetics,toxins and other predisposing factors.In this study,no statistically significant relationship was observed between HSV1 and pemphigus vulgaris.More studies must be done in this regard.关键词
单纯疱疹病毒/巨细胞病毒/EB病毒/免疫球蛋白G/寻常型天疱疮Key words
simplexvirus/cytomegalovirus/epstein-barr virus/immunoglobulin G/pemphigus vulgaris分类
医药卫生引用本文复制引用
黄芳,薛丽,冯义国,宋琳岚,耿燕..寻常型天疱疮患者血清HSV,CMV和EBV抗体IgG检测的临床意义[J].现代检验医学杂志,2017,32(4):122-124,3.基金项目
陕西省卫生厅科研基金(2012D67). （2012D67）
