天然产物研究与开发2017，Vol.29Issue(7)：1091-1095,1203,6.DOI:10.16333/j.1001-6880.2017.7.002
伯氏致病杆菌SN52中的二硫吡咯类物质及其生物活性
Dithiolopyrrolone Derivatives from Xenorhabdus bovienii SN52 and Their Antibacterial Activity
摘要
Abstract
During our search for new antibacterial agents from natural products,two new (1,2) and four known metabolites (3-6) of dithiolopyrrolone derivatives,were isolated from fermentation broth of an insect pathogenic enterobacterium,Xenorhabdus bovienii SN52.Their structures were identified on the basis of NMR and MS spectroscopic analyses and by comparison with those reported previously.Compounds 1-6 were tested antibacterial activities using 96-well microdilution broth assay,and the structure-activity relationships indicated that the antibacterial activities of dithiolopyrrolone derivatives are significant influenced by the variable substituents of side chain.关键词
伯氏致病杆菌SN52/二硫吡咯衍生物/结构鉴定/抗菌活性/结构-活性关系Key words
Xenorhabdus bovienii SN52/dithiolopyrrolone derivatives/structural elucidation/antibacterial activity/structure activity relationship分类
农业科技引用本文复制引用
张文波,王宁,姜义仁,骆世洪,于志国..伯氏致病杆菌SN52中的二硫吡咯类物质及其生物活性[J].天然产物研究与开发,2017,29(7):1091-1095,1203,6.基金项目
辽宁省攀登学者支持计划资助 （）
